<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-9254 9254-30909 Brazil 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54M, I84V, L90M L33I, Q58E, G73S, L89V L10I, V11VL, I13V, K20KI, E35DN, M36I, N37E, K55R, R57K, Q61QH, L63P, H69HR, A71V, I72M, V77VI, I85V  
>9254-30909| codons 4-99
TLWQRPILTVKIGGQLIEALLDTGADDTIIENIELPGRWKPKIVGGIGGFMRVKEYDHIP
IEICGRKVMSTVLIGPTPVNVVGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, L210W, T215Y K70T, K219KR Y181C, G190A V108I, F227L T39A, E40F, K43E, I50IV, L100LF, K101Q, K103KR, V118I, K122E, I135T, G196GE, E203K, Q207DE, H208F, R211K, H221HY, K223E, L228LH  
>9254-30909| codons 38-247
CAFLEEEGKISKVGPENPYNTPVFAIKKKNSTTWRKVVDFRELNKRTQDFWEVQLGIPHP
AGFQKRKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVASDLEIEQHRTKIKELREFLWKWGFYTP
DRKYQEEPPLHWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006