Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9254 | 9254-30909 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, I84V, L90M | L33I, Q58E, G73S, L89V | L10I, V11VL, I13V, K20KI, E35DN, M36I, N37E, K55R, R57K, Q61QH, L63P, H69HR, A71V, I72M, V77VI, I85V |
| >9254-30909| codons 4-99 TLWQRPILTVKIGGQLIEALLDTGADDTIIENIELPGRWKPKIVGGIGGFMRVKEYDHIP IEICGRKVMSTVLIGPTPVNVVGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K70T, K219KR | Y181C, G190A | V108I, F227L | T39A, E40F, K43E, I50IV, L100LF, K101Q, K103KR, V118I, K122E, I135T, G196GE, E203K, Q207DE, H208F, R211K, H221HY, K223E, L228LH |
| >9254-30909| codons 38-247 CAFLEEEGKISKVGPENPYNTPVFAIKKKNSTTWRKVVDFRELNKRTQDFWEVQLGIPHP AGFQKRKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVASDLEIEQHRTKIKELREFLWKWGFYTP DRKYQEEPPLHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |