<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-9251 9251-30908 Brazil 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, Q151M, T215F A62AV, V75I, F77L, K219E Y181C, G190A A98G, K101H T69N, V118I, K122E, D123N, I135T, T165I, R172K, F214L, L228H, V245M  
>9251-30908| codons 38-247
CTEMEKEGKISKIGPENPYNTPVFVIKKKNSNRWRKLIDLRELNKRTQDFWEVQLGIPHP
GGLHKKKSVTVLDVGDAYFSIPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSP
AIFQSSMIKILEPFKKQNPDIVICQYMDDLYVASDLEIGQHRTKIEELRQHLLRWGLFTP
DEKHQKEPPFHWMGYELHPDKWTVQPIMLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M G73T L10I, T12EK, I15IV, K20I, M36I, R41K, K55R, D60E, Q61E, I62V, L63P, I66F, C67Y, A71T, I72T, I93L  
>9251-30908| codons 4-99
TLWQRPIVKIKVGGQLIEALLDTGADDTVLEEINLPGKWKPKIIGGIGGFVRVRQYEEVP
IEFYGHKTTTTVLVGPTPVNVIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006