Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9251 | 9251-30908 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, Q151M, T215F | A62AV, V75I, F77L, K219E | Y181C, G190A | A98G, K101H | T69N, V118I, K122E, D123N, I135T, T165I, R172K, F214L, L228H, V245M |
| >9251-30908| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKKKNSNRWRKLIDLRELNKRTQDFWEVQLGIPHP GGLHKKKSVTVLDVGDAYFSIPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSP AIFQSSMIKILEPFKKQNPDIVICQYMDDLYVASDLEIGQHRTKIEELRQHLLRWGLFTP DEKHQKEPPFHWMGYELHPDKWTVQPIMLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | G73T | L10I, T12EK, I15IV, K20I, M36I, R41K, K55R, D60E, Q61E, I62V, L63P, I66F, C67Y, A71T, I72T, I93L |
| >9251-30908| codons 4-99 TLWQRPIVKIKVGGQLIEALLDTGADDTVLEEINLPGKWKPKIIGGIGGFVRVRQYEEVP IEFYGHKTTTTVLVGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |