Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9250 | 9250-30908 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | V11VI, L24I, L33F, T74P | L10I, I13V, G17E, L19I, K20R, E35D, M36I, R41K, R57K, Q61DN, I62V, L63T, E65D, I72T, L89M |
| >9250-30908| codons 4-99 TLWQRPIITVKIGEQIREALIDTGADDTVFEDINLPGKWKPKLIGGIGGFVKVKQYDNVT IDICGHKATGPVLVGPTPANIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74IV, V75VAIT, M184V, T215F | K219E | L100I, K103N | T69N, K122E, I135V, E169D, P170L, K173A, Q174K, D177N, G196E, Q207E, R211K, L228H, V245Q |
| >9250-30908| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSNRWRKVTDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILDLFRAKNPNIVIYQYVDDLYVGSDLEIEQHRTKIEELREHLLKWGFFTP DEKHQKEPPFHWMGYELHPDKWTVQPIQLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |