Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9083 | 9083-30904 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54AV, V82A, I84IV | L24I | L10I, T12S, I15V, G16GA, L19Q, K20IM, E35D, M36I, N37ND, K43KR, Q61QH, L63P, I64V, A71V, I72V, Q92K |
| >9083-30904| codons 4-99 TLWQRPIVSIKVAGQQMEALIDTGADDTVLEDIDLPGRWRPKLIGGIGGFVKVRQYDHIP VEICGHKVVGTVLVGPTPANVIGRNLLTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, V75M, M184V, L210W, T215Y | Y181YF | K43E, K122E, D123K, I135T, T200I, I202IV, H208HY, R211K |
| >9083-30904| codons 38-247 CTEMEEEGKISKIGPENPYNTPVFAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDEKFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIFQYVDDLYVGSDLEIGQHRIKVEELRQYLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |