Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9078 | 9078-30903 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I50V, I54A, V82A | L24I, L33F, Q58E | L10I, I13V, E35D, M36L, N37D, I62V, I64V |
| >9078-30903| codons 4-99 TLWQRPIVTVKIGGQLKEALIDTGADDTVFEDLDLPGRWKPKMIVGVGGFAKVREYDQVL VEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70KR, L74V, M184V | K219E | K103S, G190A | K102Q, V106L, K122E, I135T, K173Q, D177E, R211K, I244IV, V245A |
| >9078-30903| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKQSKSLTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRQQNPEIVIYQYVDDLYVASDLEIGQHRTKIEELRQHLLKWGFTTP DEKHQKEPPFLWMGYELHPDKWTVQPVALP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |