Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9076 | 9076-30902 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82S, L90M | K43T | L10V, K20R, E35D, M36I, I62V, L63P, A71V, T74S, I93L |
| >9076-30902| codons 4-99 TLWQRPVVTIKIGGQLREALLDTGADDTVLEDINLPGRWTPKMIVGIGGFVKVRQYDQVP IEICGHKVIGSVLVGPTPSNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184MV, L210W, T215Y | K219N | K103N, M230L | L234I | T39A, K43E, E44A, K64H, V106I, V111I, V118I, D121DH, K122E, S162D, G196E, T200A, H208HY, R211K, L228H, V245R |
| >9076-30902| codons 38-247 CAELEEAGKISKIGPENPYNTPVFAIHKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSITVLDIGDAYFSIPLHEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQDSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIEQHRAKIEELRQYLWKWGFYTP DNKHQKEPPFHWLGYEIHPDKWTVQPIRLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |