Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9199 | 9199-30910 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | G73S | L10I, I15V, G16A, K20M, L24F, E35D, M36I, R41K, K55R, I62V, L63P, A71V, I72L |
| >9199-30910| codons 4-99 TLWQRPIVTIKVAGQLMEALFDTGADDTVLEDINLPGKWKPKLIGGIGGFVRVRQYDQVP IEICGHKVLSTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184I, L210W | T215C, K219Q | K103N | V108I | T39A, V118I, D123N, I135T, V179I, I202V, H208Y, R211K, D218E |
| >9199-30910| codons 38-247 CAELEKEGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDVGDAYFSIPLDKNFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIIYQYIDDLYVGSDLEIGQHRTKVEELRQYLWKWGFCTP EQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |