Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9306 | 9306-30916 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82T, L90M | L10F, K43KT, G73T | K20I, M36I, D60E, I62V, L63P, I64V, A71V, I72IL, I85V |
| >9306-30916| codons 4-99 TLWQRPFVTIKIGGQLIEALLDTGADDTVLEEINLPGRWTPKMIGGIGGFVKVRQYEQVP VEICGHKVLTTVLVGPTPTNIVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | Y181C, G190A | A98G, K101H | T39K, K43E, E53D, V118I, K122E, I135T, D177E, I195L, G196E, T200TA, H208F, R211K, V245E |
| >9306-30916| codons 38-247 CKELEEEGKISKIGPDNPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP GGLHKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVICQYVDDLYVASDLELEQHRAKIEELRQFLWKWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |