Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9173 | 9173-30909 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54M, V82A, L90M | V11I, L33F, G73T, L89V | L10V, I13V, N37D, K55R, L63P, A71V, I72E, I93L |
| >9173-30909| codons 4-99 TLWQRPVITVKIGGQLKEALLDTGADDTVFEEMDLPGRWKPKLIGGIGGFMRVRQYDQIP IEICGHKVETTVLVGPTPANIIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K219KN | K101P, K103N | K43N, E44D, I94L, D123E, I135L, K166Q, D177E, G196E, T200TA, H221HY |
| >9173-30909| codons 38-247 CTELENDGKISKIGPENPYNTPVFAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGLPHP AGLPKNKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQSSMTQILEPFRKQNPEIVIYQYVDDLYVGSDLEIEQHRAKIEELRQHLWRWGFYTP DNKYQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |