Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9174 | 9174-30909 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, V82M | L24I, Q58E, L89V | W6S, L10I, I15V, E35D, M36I, N37D, R41K, I62V, L63P, Q92R |
| >9174-30909| codons 4-99 TLSQRPIVTIKVGGQLKEALIDTGADDTVLEDIDLPGKWKPKIIGGIGGFVKVREYDQVP IEICGHKAIGTVLVGPTPMNIIGRNVLTRIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74I, V75T, M184V, L210W, T215Y | A62AV | V118I, K122E, D123NS, I135T, S162C, G196E, K201M, E203K, H208Y, R211K, F214L, K223T, E224D, V245E |
| >9174-30909| codons 38-246 CTELEKEGKISKIGPENPYNTPVFVIKKKNSDKWRKITDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIEQHRTMIKELRQYLWKWGLYTP DKKHQTDPPFLWMGYELHPDKWTVQPIEL |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |