Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9172 | 9172-30904 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48Q, I54S, V82F, L90M | K43T, F53L | L10I, K20R, E35D, M36IV, N37S, R41RK, D60E, Q61E, I62V, L63P, H69HY, A71V, I72V, V77I, I93L |
| >9172-30904| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTVLEDVSLPGKWTPKIIQGIGGLSKVRQYEEVP IEICGYKVVGTVLIGPTPFNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | T39A, K43E, K64R, A98S, K102Q, V118I, K122E, I135T, I142T, Q197E, T200A, H208Y, R211K, L228H, V245M | L80LP |
| >9172-30904| codons 38-247 CAELEEEGKISKIGPENPYNTPVFAIRKKNSTKWRKVVDFREPNKRTQDFWEVQLGIPHP SGLKQKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGTRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGEHRAKIEELRQYLWKWGFYTP DNKHQKEPPFHWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |