Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9247 | 9247-30922 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | G73S | I13V, I15V, K20MT, I62V, L63P, H69QR, A71V, I72M, I93L |
| >9247-30922| codons 4-99 TLWQRPLVTVKVGGQLTEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYDQVP IEICGRKVMSTVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75T, M184MIV, T215F | A62V, K219E | K101AEPQ, Y181C, G190A | V108VI | T69TN, K122E, I135T, Q197K, T200A, D218E, L228H, V245E |
| >9247-30922| codons 38-247 CTELEKEGKISKIGPENPYNTPVFVIKKKNSNRWRKLTDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTILDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIGKHRAKIEELRQHLLRWGFFTP EEKHQKEPPFHWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |