Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9245 | 9245-30922 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46MI, I54LV, I84V, L90M | L33F, K43T | L10I, I13V, K20R, E35D, M36I, D60E, I62IV, L63P, H69Q, A71V |
| >9245-30922| codons 4-99 TLWQRPIVTVKIGGQLREALLDTGADDTIFEDINLPGRWTPKIIGGIGGFVKVRQYEQVP IEICGQKVIGTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69TADN, L210W, T215Y | V75VI | Y181YC, G190GA | W88C, D123E, I135IT, R172RK, D177E, R211K, V245M | D76DA |
| >9245-30922| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLIAFRELNKRTQDFCEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFKKQNPEIVICQYMDDLYVASDLEIGQHRTKIEELRQHLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |