Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9237 | 9237-30915 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54IV, I84V, L90M | L10F, Q58E, G73T | L19I, K20IV, E34EQ, E35D, M36I, K55KR, I62V, L63P, A71V, I72L, P79A, I93L |
| >9237-30915| codons 4-99 TLWQRPFVTIKIGGQIVEALLDTGADDTVLQDINLPGRWKPKIIGGIGGFVRVREYDQVP IEICGHKVLTTVLVGATPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | V75A, K219N | Y181C, G190A | F227L | T39A, K43E, E44A, V106I, T107S, L109I, V118I, K122E, V179VI, T200A, E203V, Q207D, H208Y, R211K, H221Y, K223Q, L228H, V245Q |
| >9237-30915| codons 38-247 CAELEEAGKISKIGPENPYNTPVFAIKKKNSTKWRKLADFRELNKRTQDFWEVQLGIPHP AGLKKKKSISVIDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIICQYMDDLYVASDLEIGQHRAKIVELRDYLWKWGFYTP DNKYQQEPPLHWMGYELHPDKWTVQPIQLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |