Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9189 | 9189-30908 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184I, L210W, T215Y | K219Q | Y181C | A98G, F227L | T39AE, E44D, K102KQ, K104KN, T107S, V118I, K122E, I135T, S162A, V179I, G196GE, Q197QK, T200A, I202V, E203K, Q207E, H208Y, R211K, K223E, L228H, V245Q |
| >9189-30908| codons 38-247 CEELEKDGKISKIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKQKNSVSVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQASMTKILEPFRKQNPDIIICQYIDDLYVGSDLEIEKHRAKVKELREYLWKWGFYTP DQKHQEEPPLHWMGYELHPDKWTVQPIQLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MIL, I54V, V82A, I84V, L90M | V11VI, L33F, Q58QE | L10I, I13V, I15V, K20R, E35D, M36I, N37DE, K55R, R57K, D60E, I62V, L63P, A71V, I85V, Q92K, I93L |
| >9189-30908| codons 4-99 TLWQRPIITVKVGGQLREALLDTGADDTVFEDIELPGRWKPKLIGGIGGFVRVKEYEQVP IEICGHKVIGTVLVGPTPANVVGRNLMTKLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |