Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9182 | 9182-30901 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54A, I84V, L90M | L10F, L33F, Q58E, T74P | T12K, I13V, I15V, K20T, E35G, M36L, R41K, I62V, L63Q, I64V, A71V, L89M, I93L |
| >9182-30901| codons 4-99 TLWQRPFVKVKVGGQLTEALLDTGADDTVFEGLNLPGKWKPKIIGGIGGFAKVREYDQVQ VEICGHKVIGPVLVGPTPVNVIGRNMMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, K70R, Q151M, M184V | A62V, V75I, F77L, F116Y, K219E | K103N | V108I | S68G, T69I, V111I, V118VI, D123E, Q174QR, E203K, F214L, H221HY |
| >9182-30901| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKRKDGIRWRKLIDLRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDIGDAYYSIPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFRKRNPDIVIYQYVDDLYVGSDLEIGQHRTKIKELRQHLLRWGLTTP DEKYQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |