Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9181 | 9181-30901 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69TADN, V75M, L210W, T215Y | K219R | K101E, G190A | V108I, F227L | K43Q, E44D, V60I, V90I, V118I, K122E, I135T, T139K, T200I, E203K, H208Y, R211K, K223E, L228H |
| >9181-30901| codons 38-247 CTELEQDGKISKIGPENPYNTPIFAIKKKNSNKWRKLMDFRELNKRTQDFWEIQLGIPHP AGLEKKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSTNNEKPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVASDLEIGQHRIKIKELRQYLWKWGFYTP DRKHQEEPPLHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82S, L90M | K43T | L10V, T12TP, L19LI, K20R, E35D, M36I, R57RK, I62V, L63P, A71V, Q92K, I93L, C95F |
| >9181-30901| codons 4-99 TLWQRPVVPIKIGGQIREALLDTGADDTVLEDINLPGRWTPKLIGGIGGFVKVKQYDQVP IEICGHKVIGTVLVGPTPSNIIGRNLMTKLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |