Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9352 | 9352-30924 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215Y | K219N | Y188L | K43E, V60I, E79ED, V118I, K122E, D123E, S162C, D177E, T200A, R211K, V245K |
| >9352-30924| codons 38-247 CTELEEEGKISKIGPENPYNTPIFAIKKKNSTKWRKLMDFRDLNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPEIVIYQYMDDLLVGSDLEIGQHRAKIEELRQHLWKWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPIKLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82A, I84V, L90M | F53L | L10V, I15V, K20R, E35D, M36I, N37NS, R41K, R57K, D60E, Q61D, I62V, L63P, A71V, I85V |
| >9352-30924| codons 4-99 TLWQRPVVTIKVGGQLREALLDTGADDTVLEDISLPGKWKPKIIGGIGGLIKVKQYEDVP IEICGHKVIGTVLVGPTPANVVGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |