Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9345 | 9345-30923 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, L210W, T215Y | K219KR | L100I, K103N | E42EG, K43Q, E44D, K65KE, V111I, V118I, D123E, I135T, D177E, E203EK, Q207E, H208HY, R211K, K223Q |
| >9345-30923| codons 38-247 CTELGQDGKISKIGPENPYNTPVFAIKEKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDIGDAYFSIPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVIYQYMDDLYVGSDLEIGQHRTKIKELREYLWKWGFYTP DRKHQQEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I50IV, I54V, V82A, I84IV | Q58E | L10I, I15V, G16GE, L19I, K20R, E35D, M36I, R57K, D60DE, I62V, L63S, I64L, A71V, V77VI, I93IL |
| >9345-30923| codons 4-99 TLWQRPIVTIKVEGQIREALLDTGADDTVLEDINLPGRWKPKIIGGVGGFVKVKEYEQVS LEICGHKVIGTVLIGPTPANVIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |