<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-9273 9273-30918 Brazil 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, G48V, I50V, I54T, V82A, L90M L33F, K43T L10IV, K20R, E34N, E35D, M36I, N37NS, R41K, Q61EG, I62V, L63ADHP, I64IL, A71V, I72IT, T74S, L89M, I93L  
>9273-30918| codons 4-99
TLWQRPVVTIKIGGQLREALLDTGADDTVFNDISLPGKWTPKIIVGVGGFTKVRQYDGVP
LEICGHKVTGSVLVGPTPANIIGRNMMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184MV, L210W, T215Y K219D Y181C, G190A V108I, F227L T39A, E44D, K101Q, L109V, V118I, D123E, V189I, G196E, I202V, E203K, Q207E, H208Y, R211K, W212C, K223E, L228H E224KT
>9273-30918| codons 38-247
CAELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP
AGLQKKKSVTIVDVGDAYFSIPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIVICQYVDDLYIASDLEIEQHRTKVKELREYLWKCGFYTP
DDKHQETPPLHWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006