Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9273 | 9273-30918 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I50V, I54T, V82A, L90M | L33F, K43T | L10IV, K20R, E34N, E35D, M36I, N37NS, R41K, Q61EG, I62V, L63ADHP, I64IL, A71V, I72IT, T74S, L89M, I93L |
| >9273-30918| codons 4-99 TLWQRPVVTIKIGGQLREALLDTGADDTVFNDISLPGKWTPKIIVGVGGFTKVRQYDGVP LEICGHKVTGSVLVGPTPANIIGRNMMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184MV, L210W, T215Y | K219D | Y181C, G190A | V108I, F227L | T39A, E44D, K101Q, L109V, V118I, D123E, V189I, G196E, I202V, E203K, Q207E, H208Y, R211K, W212C, K223E, L228H | E224KT |
| >9273-30918| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTIVDVGDAYFSIPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYIASDLEIEQHRTKVKELREYLWKCGFYTP DDKHQETPPLHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |