Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9270 | 9270-30918 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54S, V82A, L90M | K43T | L10I, I13V, I15V, Q18H, K20I, M36I, N37D, I62V, L63P, A71L, I93L |
| >9270-30918| codons 4-99 TLWQRPIVTVKVGGHLIEALLDTGADDTVLEEIDLPGRWTPKLIVGIGGFSKVRQYDQVP IEICGHKLIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K70KQ | K103N | T39TA, E40F, K43E, K122E, D123E, I135T, E138Q, S162C, I167V, I178L, G196E, Q207E, H208Y, R211K, D237E |
| >9270-30918| codons 38-247 CAFLEEEGKISKIGPENPYNTPVFAIKKKNSTQWRKLMDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSTNNQTPGIRYQYNVLPQGWKGSP AIFQCSMTKVLEPFRKQNPDLVIYQYVDDLYVGSDLEIEQHRTKIEELREYLWKWGFYTP DKKHQKEPPFLWMGYELHPEKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |