<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-9266 9266-30915 Brazil 2003 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y K219R   A98G, V108I, F227FL T39M, E44D, V118I, K122E, I135T, I142V, S162Y, E169D, K173A, Q174K, I178IM, E203K, Q207E, H208Y, R211K, K223E, L228H, P243S, V245Q  
>9266-30915| codons 38-247
CMELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP
GGLKKKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSP
AIFQYSMTKILDPFRAKNPDMVIYQYVDDLYVGSDLEIGQHRTKIKELREYLWKWGFYTP
DRKHQEEPPLHWMGYELHPDKWTVQSIQLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, L76V, V82A, L90M   L10V, I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, L63P, H69R, K70R, A71V, I72IV, L89M, I93L  
>9266-30915| codons 4-99
TLWQRPVVTIKVGGQLREALLDTGADDTVLEDIDLPGKWKPKLIGGIGGFVKVKQYDNIP
IEICGRRVVGTVVVGPTPANIIGRNMMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006