Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9217 | 9217-30908 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46FL, I54V, V82A, L90M | L33I | L10I, I15V, K20R, E35D, M36I, N37E, R41K, K43R, R57K, Q61N, L63A, A71V, Q92K, I93L |
| >9217-30908| codons 4-99 TLWQRPIVTIKVGGQLREALLDTGADDTVIEDIELPGKWRPKLIGGIGGFVKVKQYDNIA IEICGHKVIGTVLVGPTPANIIGRNLMTKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, T215F | K219Q | K49KR, I135V, S162Y, E169D, K173A, Q174K, I178L, V179I, E203D, Q207E, H208Y, R211K, D218E, L228H, Q242QH |
| >9217-30908| codons 38-244 CTELEKEGKISRIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQYSMTKILDPFRAKNPDLIIYQYVDDLYVGSDLEIGQHRTKIDELREYLLKWGFFTP EQKHQKEPPFHWMGYELHPDKWTVHPI |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |