Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9218 | 9218-30908 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215Y | K219R | K103N | K43N, E44D, V90I, I94L, V118I, K122E, I135L, I142V, G196E, T200TA, E203D, H208Y, R211K, H221Y, V245K |
| >9218-30908| codons 38-247 CTELENDGKISKIGPENPYNTPVFAIKKKNSTKWRKLMDFRELNKRTQDFWEIQLGLPHP AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSLNNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIDELRQYLWKWGFYTP DRKYQKEPPFLWMGYELHPDKWTVQPIKLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54AT, V82A | L10F, L24I, L33F, K43T | G16A, L19LV, E34Q, K55KR, L63P, A71V, I72V, Q92K, I93L |
| >9218-30908| codons 4-99 TLWQRPFVTIKIAGQVKEALIDTGADDTVFQEMNLPGRWTPKIIGGIGGFTRVRQYDQIP IEICGHKVVGTVLVGPTPANIIGRNLLTKLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |