Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9040 | 9040-30901 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, L76V, I84V, L90M | L10F, V11VI, L89LV | I13V, Q18H, K20I, E34EK, M36I, I62V, L63P, A71V |
| >9040-30901| codons 4-99 TLWQRPFITVKIGGHLIEALLDTGADDTVLKEINLPGRWKPKMIGGIGGFVKVRQYDQVP IEICGHKVIGTVVVGPTPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, M184V, L210W, T215Y | K219E | G190A | V60I, V118I, K122E, D123E, I135T, S162A, K166Q, D177E, E203K, R211K, D218E, V245KM |
| >9040-30901| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQASMTQILEPFRKQNPEIVIYQYVDDLYVASDLEIGQHRTKIKELRQHLWKWGFYTP EEKHQKEPPFLWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |