<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-9036 9036-30825 Brazil 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, G73S V11L, T12P, I15V, G17E, Q18H, K20I, M36MI, L63P, A71V, I72L, I85V, I93L  
>9036-30825| codons 4-99
TLWQRPFLPIKVGEHLIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYDQIP
IEICGHKVLSTVLVGPTPVNVVGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y V75M, K219N Y181V, G190A A98G, F227L K43Q, E44D, K49R, V60I, V106VI, V111I, K122E, D123DE, I135IV, S162D, S163T, M164I, I167V, E169D, I178F, V179I, T200A, E203K, H208Y, R211K, K223E  
>9036-30825| codons 38-247
CTELEQDGKISRIGPENPYNTPIFAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHP
GGLKKKKSITVLDIGDAYFSVPLDEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP
AIFQDTITKVLDPFRKQNPDFIIVQYMDDLYVASDLEIGQHRAKIKELRQYLWKWGFYTP
DNKHQEEPPLLWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006