Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9068 | 9068-30827 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, M46MI, I47IV, I54V, V82T, I84V, L90M | L33LF, F53FL, Q58E | L10IV, I15V, K20R, E34EQ, E35D, M36I, K55KR, D60E, L63P, A71IV, I85IV, Q92QK | L24*W |
| >9068-30827| codons 4-99 TLWQRPVVTIKVGGQLREALWDTGADDTIFQDINLPGRWKPKIVGGIGGLVRVREYEQIP IEICGHKVIGTVLVGPTPTNVVGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74IV, M184V, L210W, T215Y | D67G, K219N | K103KN, G190GA | S68G, K102Q, V118I, K122E, D123N, I135T, T139TI, E203EK, Q207KN, H208Y, R211K, K223Q, D237DN, V245T |
| >9068-30827| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKGGTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKQNKSVTVLDVGDAYFSIPLDENFRKYTAFTIPSTNNEIPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVASDLEIGQHRTKIKELRNYLWKWGFYTP DNKHQQEPPFLWMGYELHPNKWTVQPITLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |