<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-9068 9068-30827 Brazil 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32VI, M46MI, I47IV, I54V, V82T, I84V, L90M L33LF, F53FL, Q58E L10IV, I15V, K20R, E34EQ, E35D, M36I, K55KR, D60E, L63P, A71IV, I85IV, Q92QK L24*W
>9068-30827| codons 4-99
TLWQRPVVTIKVGGQLREALWDTGADDTIFQDINLPGRWKPKIVGGIGGLVRVREYEQIP
IEICGHKVIGTVLVGPTPTNVVGRNLMTKIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74IV, M184V, L210W, T215Y D67G, K219N K103KN, G190GA   S68G, K102Q, V118I, K122E, D123N, I135T, T139TI, E203EK, Q207KN, H208Y, R211K, K223Q, D237DN, V245T  
>9068-30827| codons 38-247
CTELEKEGKISKIGPENPYNTPVFAIKKKGGTKWRKVVDFRELNKRTQDFWEVQLGIPHP
AGLKQNKSVTVLDVGDAYFSIPLDENFRKYTAFTIPSTNNEIPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVASDLEIGQHRTKIKELRNYLWKWGFYTP
DNKHQQEPPFLWMGYELHPNKWTVQPITLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006