Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9289 | 9289-30930 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219Q | K101E, Y181C, G190S | T39L, K49R, V60I, T69TN, S162H, E169D, K173T, Q174K, G196E, Q207E, L228H, V245Q |
| >9289-30930| codons 38-247 CLEMEKEGKISRIGPENPYNTPIFAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLEKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQHSMTKILDPFRTKNPDIVICQYMDDLYVSSDLEIEQHRTKIEELREHLLRWGFFTP DQKHQKEPPFHWMGYELHPDKWTVQPIQLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84IV | L24I, L33LF | L10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63LP, A71V, L89M, Q92K, I93L |
| >9289-30930| codons 4-99 TLWQRPIVTIKVGGQLREALIDTGADDTVFEDINLPGKWKPKLIGGIGGFVKVKQYDNIP IEICGHKVIGTVLVGPTPANVIGRNMLTKLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |