Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9286 | 9286-30929 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L76V, I84V | L10F, L33F | I15V, G16E, K20V, M36L, N37NI, P39S, K55KR, I62V, T74S, I85V, L89I, T91A |
| >9286-30929| codons 4-99 TLWQRPFVTIKVEGQLVEALLDTGADDTVFEELILSGRWKPKIIGGIGGFIRVRQYDQVL IEICGHKAIGSVVVGPTPVNVVGRNILAQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | K219KQR | K122E, D123N, I135T, K166R, G196E, H208HY, R211RK, L228R, V245M |
| >9286-30929| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRTKIEELRQYLWKWGFYTP DRKHQKEPPFRWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |