Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9258 | 9258-30918 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | K219R | K101E, Y181C, G190A | A98G, F227L | K43N, E44D, V118I, K122E, S162N, Q174K, D177N, I178M, Q197E, E203K, Q207E, K223E, V245T |
| >9258-30918| codons 38-247 CTELENDGKISKIGPENPYNTPVFAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHP GGLEKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQNSMTKILEPFRKKNPNMVICQYVDDLYVASDLEIGEHRTKIKELREHLWRWGFYTP DRKHQEEPPLLWMGYELHPDKWTVQPITLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, I84V, L90M | L33F, G73T | L10I, I13V, L19I, R41K, L63LM, I64V, H69Y, A71I, I72IM, V77L, I93L |
| >9258-30918| codons 4-99 TLWQRPIVTVKIGGQIKEALLDTGADDTIFEEMNLPGKWKPKIVGGIGGFLKVRQYDQIM VEICGYKIMTTVLLGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |