Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9249 | 9249-30904 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I54V, V82A, L90M | K43T, L89V | L10I, T12N, L19I, E21EK, R41K, K55R, L63P, A71I, I85IV |
| >9249-30904| codons 4-99 TLWQRPIVNIKIGGQIKKALLDTGADDTILEEMNLPGKWTPKIIGGIGGFVRVRQYDQIP IEICGHKIIGTVLVGPTPANIVGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T215F | K219Q | K103N, Y181C | A98AG, K238KT | T39S, V60I, V90VI, D121Y, K122E, I135T, E138EQ, I142V, S162Y, D177E, I178L, V179IL, I195L, H208Y, R211K, H221HY, E224D |
| >9249-30904| codons 38-247 CSELEKEGKISKIGPENPYNTPIFAIKKKNSTKWRKLVDFRELNKRTQDFWEIQLGIPHP GGLKKNKSVTVLDVGDAYFSVPLYEDFRKYTAFTIPSTNNQTPGVRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPELLICQYMDDLYVGSDLELGQHRTKIEELRQYLLKWGFFTP DQKYQKDPPFLWMGYELHPDTWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |