<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-9249 9249-30904 Brazil 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I54V, V82A, L90M K43T, L89V L10I, T12N, L19I, E21EK, R41K, K55R, L63P, A71I, I85IV  
>9249-30904| codons 4-99
TLWQRPIVNIKIGGQIKKALLDTGADDTILEEMNLPGKWTPKIIGGIGGFVRVRQYDQIP
IEICGHKIIGTVLVGPTPANIVGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T215F K219Q K103N, Y181C A98AG, K238KT T39S, V60I, V90VI, D121Y, K122E, I135T, E138EQ, I142V, S162Y, D177E, I178L, V179IL, I195L, H208Y, R211K, H221HY, E224D  
>9249-30904| codons 38-247
CSELEKEGKISKIGPENPYNTPIFAIKKKNSTKWRKLVDFRELNKRTQDFWEIQLGIPHP
GGLKKNKSVTVLDVGDAYFSVPLYEDFRKYTAFTIPSTNNQTPGVRYQYNVLPQGWKGSP
AIFQYSMTKILEPFRKQNPELLICQYMDDLYVGSDLELGQHRTKIEELRQYLLKWGFFTP
DQKYQKDPPFLWMGYELHPDTWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006