<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-9186 9186-30901 Brazil 2003 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A L24I, L33F, K43T, F53L, T74P L10I, I13V, I15V, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I64L, A71V, I72T, L89I, I93L  
>9186-30901| codons 4-99
TLWQRPIVTVKVGGQLREALIDTGADDTVFEDINLPGKWTPKLIGGIGGLVRVKQYDNIL
LEICGHKVTGPVLVGPTPANIIGRNILTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, M184V, T215F K219Q Y181YC   T39A, K49R, T69N, K101KQ, K122E, D123DN, I135T, S162C, I167V, E169D, K173A, Q174K, I178L, E194Q, G196E, I202IV, Q207E, H208Y, R211K, D218E, L228H, V245Q  
>9186-30901| codons 38-247
CAELEKEGKISRIGPENPYNTPVFAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHP
AGLQKKKSVTVLDVGDAYFSVPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQCSMTKVLDPFRAKNPDLVICQYVDDLYVGSDLQIEQHRTKVEELREYLLKWGFFTP
EQKHQKEPPFHWMGYELHPDKWTVQPIQLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006