Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9349 | 9349-30923 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, G48M, I54M, V82A | L33F, F53L | L10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I72T, T74S, L89I |
| >9349-30923| codons 4-99 TLWQRPIVTIKVGGQLREALLDTGADDTIFEDINLPGKWKPKIVMGIGGLMKVKQYDNIL IEICGHKATGSVLVGPTPANIIGRNILTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, V75M, T215F | K219W | K103KN, Y188L | T39A, K43KE, V60I, K101KI, V106L, L109V, K122E, D123N, I135V, E169D, R172RK, K173A, Q174K, T200A, E203D, Q207A, R211T, D218E, L228H |
| >9349-30923| codons 38-247 CAELEEEGKISKIGPENPYNTPIFAIKKKNSDRWRKLMDFRELNKRTQDFWEVQLGIPHP AGLIKNKSLTVVDVGDAYFSVPLDENFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILDPFKAKNPDIVIYQYMDDLLVGSDLEIGQHRAKIDELRAHLLTWGFFTP EWKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |