Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9272 | 9272-30922 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75M, M184V, L210W, T215Y | K219N | L100I, K103N | T39A, K43E, E44A, K102R, V118VI, D123DE, I135V, K173T, Q174K, D177G, G196E, T200A, E203AV, Q207E, H208Y, R211K, H221HY, L228HR, Q242QH, V245Q |
| >9272-30922| codons 38-247 CAELEEAGKISKIGPENPYNTPVFAIKKKDSTKWRKLMDFRELNKRTQDFWEVQLGIPHP AGIKRNKSVTVLDVGDAYFSIPLDKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRTKNPGIVIYQYVDDLYVGSDLEIEQHRAKIVELREYLWKWGFYTP DNKYQKEPPFRWMGYELHPDKWTVHPIQLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90LM | L10I, I15V, L19Q, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I62IV, T74A, L89I, I93L |
| >9272-30922| codons 4-99 TLWQRPIVTIKVGGQQREALLDTGADDTVLEDINLPGKWKPKLIGGIGGFVRVKQYDNVL IEICGHKAIGAVLVGPTPANIIGRNIMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |