<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-9272 9272-30922 Brazil 2003 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, L90LM   L10I, I15V, L19Q, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I62IV, T74A, L89I, I93L  
>9272-30922| codons 4-99
TLWQRPIVTIKVGGQQREALLDTGADDTVLEDINLPGKWKPKLIGGIGGFVRVKQYDNVL
IEICGHKAIGAVLVGPTPANIIGRNIMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, V75M, M184V, L210W, T215Y K219N L100I, K103N   T39A, K43E, E44A, K102R, V118VI, D123DE, I135V, K173T, Q174K, D177G, G196E, T200A, E203AV, Q207E, H208Y, R211K, H221HY, L228HR, Q242QH, V245Q  
>9272-30922| codons 38-247
CAELEEAGKISKIGPENPYNTPVFAIKKKDSTKWRKLMDFRELNKRTQDFWEVQLGIPHP
AGIKRNKSVTVLDVGDAYFSIPLDKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRTKNPGIVIYQYVDDLYVGSDLEIEQHRAKIVELREYLWKWGFYTP
DNKYQKEPPFRWMGYELHPDKWTVHPIQLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006