Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7207 | 7207-30911 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L24I, K43T, G73T | L10I, I13M, I15V, G16E, K20I, E35D, M36I, I62V, L63H, C67Y, A71V, I72V |
| >7207-30911| codons 1-99 PQITLWQRPIVTMKVEGQLIEALIDTGADDTVLEDINLPGRWTPKMIGGIGGFVKVRQYD QVHIEIYGHKVVTTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K65R, D67~, Y115F, Q151M, L210W, T215Y | A62V, T69G, V75I, F116Y, K219E | K103N, Y181C, G190A | V179F | P4T, E6D, K122E, I142V, S162C, S163SC, I167IV, R172K, I202V, Q207E, R211K, L228R, V245E, A272P, P294Q, K366KR, T386I, K390R |
| >7207-30911| codons 1-399 PISTIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FVIKRK~SGKWRKLIDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAFYSVPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPMGWKGSPAIFQCCMTKVLEPFKKQNPDIFI CQYMDDLYVASDLEIGQHRTKVEELREHLWKWGFYTPDEKHQKEPPFRWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIQLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVRQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |