Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7206 | 7206-30911 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48M, I54V, V82A | L24I | L10I, T12N, L19I, K20KR, M36MI, N37D, L63P, A71T, V77VI, N83S, T91TA |
| >7206-30911| codons 1-99 PQITLWQRPIVNIKIGGQIREALIDTGADDTVLEEIDLPGRWKPKMIMGIGGFVKVRQYD QIPIEICGHKTIGTVLIGPTPASIIGRNLLAQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219Q | K103N | V8VI, K20R, E28EK, K49KR, T69N, K102KR, K122E, D123N, I135T, Q145C, G196E, L228H, Y271YH, T286A, P294Q, E297Q, R356K, I382IV, K390R |
| >7206-30911| codons 1-400 PISPIETIPVKLKPGMDGPRVKQWPLTKEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSTNNETPGIRYCYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIHAGIKVKQLCKLLRGAKALTEVIQLTQEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVKQLTEAVQKIATESIVVWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |