<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7206 7206-30911 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48M, I54V, V82A L24I L10I, T12N, L19I, K20KR, M36MI, N37D, L63P, A71T, V77VI, N83S, T91TA  
>7206-30911| codons 1-99
PQITLWQRPIVNIKIGGQIREALIDTGADDTVLEEIDLPGRWKPKMIMGIGGFVKVRQYD
QIPIEICGHKTIGTVLIGPTPASIIGRNLLAQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, M184V, T215F K219Q K103N   V8VI, K20R, E28EK, K49KR, T69N, K102KR, K122E, D123N, I135T, Q145C, G196E, L228H, Y271YH, T286A, P294Q, E297Q, R356K, I382IV, K390R  
>7206-30911| codons 1-400
PISPIETIPVKLKPGMDGPRVKQWPLTKEKIKALVEICTEMEKEGKISRIGPENPYNTPV
FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRNKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSTNNETPGIRYCYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIHAGIKVKQLCKLLRGAKALTEVIQLTQEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGA
HTNDVKQLTEAVQKIATESIVVWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006