Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7204 | 7204-30829 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74LV, M184V, T215Y | G190GA | S3C, K43KE, E44D, V90I, K101Q, D123E, I142V, I178L, V179I, E203D, Q207E, R211K, V245N, K277R, T286A, A288T, E297K, E312V, Q334L, F346Y, T386I |
| >7204-30829| codons 1-399 PICPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEIQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLII YQYVDDLYVASDLEIGQHRTKIDELREHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPINLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKTLTEVIPLTKEAE LELAENREILKVPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPYKNLKTGKYARMRGA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54T, V82A, L90M | L33F | L10I, G16GE, K20R, E34Q, E35D, M36I, N37E, R41K, I62V, L63C, A71V, I93L |
| >7204-30829| codons 1-99 PQITLWQRPIVTIKIEGQLREALLDTGADDTVFQDIELPGKWKPKMIVGIGGFTKVRQYD QVCIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |