Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7203 | 7203-30814 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, V82T | L10F, L24I, G73GS | I13V, I15V, K20T, N37D, I62V, L63P, A71V, T74S, V77I |
| >7203-30814| codons 1-99 PQITLWQRPFVTVKVGGQLTEALIDTGADDTVLEEMDLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGHKVISSVLIGPTPTNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R | K219H | V108VI, F227FL | T39TK, K43Q, K49KR, V60VI, V90VI, K122P, I135T, I178M, E203V, D218E, V245VE, T286A, P294Q, D324DE, I326IM, Y342YF, G359GS, K366R, T386I, K390R |
| >7203-30814| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICKEMEQEGKISRIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTILDVGDAYFSVPL DPDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLYVGSDLEIGQHRTKIVELRQHLLRWGFTTPEHKHQKEPPLLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIQLTEEAE LELAENREILKEPVHGVYYDPSKELMAEIQKQGQGQWTYQIFQEPFKNLKTGKYARMRSA HTNDVRQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |