Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7195 | 7195-30729 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I | N88T | L10I, K20R, E35D, M36I, K45R, L63P, A71V, V77I, I93L |
| >7195-30729| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDINLPGRWKPRIIGGIGGFIKVRQYD QIPIEICGHKVIGTVLIGPTPVNIIGRTLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, Y115YF, M184V, T215Y | V179VD | K103KR, K122E, I135IT, I142IV, K173KR, Q174H, T200A, Q207N, R211K, V245K, A272P, K275KR, I293V, K311R, I329V, G333DE, T338S, T369TA, A371AV, T377V, K390R, E399ED, A400AT |
| >7195-30729| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAFFSVPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRHNPDIDI YQYVDDLYVGSDLEIGQHRAKIEELRNHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILREPVHGVYYDPSKDLIAEVQKQEQGQWSYQIYQEPFKNLKTGKYARMRGA HTNDVKQLAEVVQKIAVESIVIWGKTPKFRLPIQKETWDT |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |