<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7195 7195-30729 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I N88T L10I, K20R, E35D, M36I, K45R, L63P, A71V, V77I, I93L  
>7195-30729| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDINLPGRWKPRIIGGIGGFIKVRQYD
QIPIEICGHKVIGTVLIGPTPVNIIGRTLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, Y115YF, M184V, T215Y     V179VD K103KR, K122E, I135IT, I142IV, K173KR, Q174H, T200A, Q207N, R211K, V245K, A272P, K275KR, I293V, K311R, I329V, G333DE, T338S, T369TA, A371AV, T377V, K390R, E399ED, A400AT  
>7195-30729| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAFFSVPL
DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRHNPDIDI
YQYVDDLYVGSDLEIGQHRAKIEELRNHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGTKALTEVVPLTEEAE
LELAENREILREPVHGVYYDPSKDLIAEVQKQEQGQWSYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLAEVVQKIAVESIVIWGKTPKFRLPIQKETWDT

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006