Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7194 | 7194-30725 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K101KE, Y181C | P4PS, T39E, E44D, V106VI, V118I, D123E, I142V, S162D, K166R, R172RK, D177DE, I202V, E203D, R211K, H221Y, A272P, T286A, P294Q, G359S, A371V, I375IV, A376S, T386TI |
| >7194-30725| codons 1-399 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICEELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSITVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQDSMTRILEPFKKQNPEIVI CQYVDDLYVGSDLEIGQHRTKVDELRQHLWKWGFYTPDKKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIQLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKVSTESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, L33F, G73S | T4TA, E34EQ, L63P, I66IF, C67CY, A71V, I72L, I93L |
| >7194-30725| codons 1-99 PQIALWQRPFVTIKIGGQLKEALLDTGADDTVFQEMNLPGRWKPKIIGGIGGFVKVRQYD QIPIEFYGHKVLSTVLVGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |