<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7185 7185-30721 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74LV, M184V, L210W, T215Y K219R, N348I K103N, Y181YC V108I T39E, E44D, T69N, A98S, V118VI, K122E, I135T, I142V, D192DN, T200A, E203D, R211K, K223Q, L228R, E297K, I329L, M357T, T369A  
>7185-30721| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICEELEKDGKISKIGPENPYNTPV
FAIKKKDSNKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTILDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYVDDLYVGSNLEIGQHRAKIDELRQHLWKWGFYTPDRKHQQEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKILKTGKYARTRGA
HTNDVKQLAEAVQKIATESIVIWGKTPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M G73S L10I, K20I, E35D, M36I, N37D, D60E, I62V, L63P, A71V, I72R, V77I, I85V  
>7185-30721| codons 1-99
PQITLWQRPIVTIKIGGQLIEALLDTGADDTVLEDIDLPGRWKPKIIGGIGGFVKVRQYE
QVPIEICGHKVRSTVLIGPTPVNVVGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006