<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7182 7182-30910 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, L90M L33F, K43KT, G73S, T74PS L10V, G16GA, R41RK, K55R, Q61E, L63P, A71V, V77I, I93L  
>7182-30910| codons 1-99
PQITLWQRPVVTIKIAGQLKEALLDTGADDTVFEEMNLPGKWTPKLIGGIGGFVRVRQYD
EIPIEICGHKVISSVLIGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74LV, L210W, T215Y   Y188L   V35I, T39A, E44ED, V118I, K122E, I142V, T165TI, G196E, Q207E, R211K, A272AT, T286N, I293V, K311R, D324E, I329L, G359S, V365I  
>7182-30910| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPDIVI
YQYMDDLLVGSDLEIEQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYTGIKVKQLCKLLRGNKALTEVVPLTEEAE
LELAENREILREPVHGVYYDPSKELIAELQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDIKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006