Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7182 | 7182-30910 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L33F, K43KT, G73S, T74PS | L10V, G16GA, R41RK, K55R, Q61E, L63P, A71V, V77I, I93L |
| >7182-30910| codons 1-99 PQITLWQRPVVTIKIAGQLKEALLDTGADDTVFEEMNLPGKWTPKLIGGIGGFVRVRQYD EIPIEICGHKVISSVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74LV, L210W, T215Y | Y188L | V35I, T39A, E44ED, V118I, K122E, I142V, T165TI, G196E, Q207E, R211K, A272AT, T286N, I293V, K311R, D324E, I329L, G359S, V365I |
| >7182-30910| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPDIVI YQYMDDLLVGSDLEIEQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYTGIKVKQLCKLLRGNKALTEVVPLTEEAE LELAENREILREPVHGVYYDPSKELIAELQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDIKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |