<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7181 7181-30904 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L210W, T215Y   Y188L V179VDE T39A, S68G, V106I, V118I, K122KE, I135T, Q174K, Q207E, R211K, T286A, E297K, E312H, G333E, T338S, F346Y, M357T, G359S, A371V Y232YH
>7181-30904| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV
FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIEI
YQYMDDLLVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGHELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE
LELAENREILKHPVHGVYYDPSKDLIAEIQKQEQGQWSYQIYQEPYKNLKTGKYARTRSA
HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, V82A, I84V L24I, L33F L10I, T12P, I13V, K14R, L63P, I66V, T74S, V77VI, L89M, I93L  
>7181-30904| codons 1-99
PQITLWQRPIVPVRIGGQLKEALIDTGADDTVFEEMNLPGRWKPKLIGGIGGFIKVRQYD
QIPIEVCGHKAIGSVLIGPTPANVIGRNMLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006