Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7181 | 7181-30904 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, V82A, I84V | L24I, L33F | L10I, T12P, I13V, K14R, L63P, I66V, T74S, V77VI, L89M, I93L |
| >7181-30904| codons 1-99 PQITLWQRPIVPVRIGGQLKEALIDTGADDTVFEEMNLPGRWKPKLIGGIGGFIKVRQYD QIPIEVCGHKAIGSVLIGPTPANVIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | Y188L | V179VDE | T39A, S68G, V106I, V118I, K122KE, I135T, Q174K, Q207E, R211K, T286A, E297K, E312H, G333E, T338S, F346Y, M357T, G359S, A371V | Y232YH |
| >7181-30904| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIEI YQYMDDLLVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGHELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILKHPVHGVYYDPSKDLIAEIQKQEQGQWSYQIYQEPYKNLKTGKYARTRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |