Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7172 | 7172-30707 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | F53L, G73S | L10I, I15V, G16GE, K20I, E35D, M36I, N37K, R41K, R57K, I62V, L63LP, A71V |
| >7172-30707| codons 1-99 PQITLWQRPIVTIKVEGQLIEALLDTGADDTVLEDIKLPGKWKPKIIGGIGGLVKVKQYD QVPIEICGHKVISTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, T215F | K219Q | V35VI, K43E, V118I, K122E, I135T, G196GR, R211A, F214L, K223Q, L228H, A272P, K277R, A288T, E297A, G333E, M357V, A360T, K395R, A400AT |
| >7172-30707| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEEEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIRQHRTKIEELRQHLLAWGLFTPDQKHQQEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKTLTEVIPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYARVRGT HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQRETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |