Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7171 | 7171-30701 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54T, V82A, L90M | L33F, L89V | L10V, I13IV, K14R, L19I, E34Q, R41K, I62IV, L63P, A71I, I72T, V77I, I93L |
| >7171-30701| codons 1-99 PQITLWQRPVVTVRIGGQIKEALLDTGADDTVFQEMNLPGKWKPKLIVGIGGFTKVRQYD QVPIEICGHKITGTVLIGPTPANIIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219N | K101E, K103N, Y181C, G190A | V35I, E44D, R83K, V118I, K122E, I135T, I178M, G196E, H208Y, R211K, D218DE, V245M, A272P, K277R, I293V, E297K, D324E, R358K, G359S, A371V, A376S |
| >7171-30701| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKKTQDFWEVQLGIPHPAGLEKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI CQYMDDLYVASDLEIEQHRTKIEELRQYLWKWGFYTPENKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKSA HTNDVKQLTEVVQKISTESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |