Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7168 | 7168-30627 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48GA, I54V, V82A, L90M | L10I, L19I, K20R, E35D, M36I, L63P, A71V, Q92QK, I93L |
| >7168-30627| codons 1-99 PQITLWQRPIVTIKIGGQIREALLDTGADDTVLEDINLPGRWKPKMIAGIGGFVKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67DN, K70R, M184V, T215F | K219Q, N348I | G190A | V179I, E194K, G196E, Q207A, R211K, A272P, K277R, E300EK, S322A, Q334N, G335D, M357T, R358K, E370G |
| >7168-30627| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLYVASDLKIEQHRTKIEELRAHLLKWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAK LELAENREILKEPVHGVYYDPAKDLIAEIQKQGNDQWTYQIYQEPFKILKTGKYARTKGA HTNDVKQLTGAVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |