Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7167 | 7167-30613 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | V75S, K219N | Y181C, G190S | V35I, E44D, K49R, K101Q, V111VIM, V118I, K122E, I135T, S162A, E169D, T200E, E203K, H208Y, R211K, K223E, A272P, I293V, E297A, I329V, Q334E, M357R, R358K, G359S, T386I |
| >7167-30613| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKDGKISRIGPENPYNTPV FAIKKKNSTKWRKLSDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDMGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILDPFRKQNPDIVI CQYMDDLYVSSDLEIGQHREKIKELRQYLWKWGFYTPDNKHQEEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGEGQWTYQIYQEPFKNLKTGKYARRKSA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48M, I54S, V82A, L90M | L33F | L10I, K20R, E35D, M36I, N37D, I62V, L63P, A71V, I72V, I93L |
| >7167-30613| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVFEDIDLPGRWKPKLIMGIGGFSKVRQYD QVPIEICGHKVVGTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |