Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7165 | 7165-30611 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48A, I54V, V82A | L10R, T12TP, K20R, E35D, M36I, N37ND, L63P, I64V, A71V, V77I, T91A, Q92QK, I93L |
| >7165-30611| codons 1-99 PQITLWQRPRVPIKIGGQLREALLDTGADDTVLEDIDLPGRWKPKLIAGIGGFVKVRQYD QIPVEICGHKVIGTVLIGPTPANIIGRNLLAKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219KR | V35M, K43E, E44A, K101Q, V118I, I135V, V179I, R211K, Y271F, E297K, H315Y, V317VA, D324E, G333E, Q334H, G359S, A371V, T377L |
| >7165-30611| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDRKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIFAGIKVKQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVYGAYYDPSKELIAEIQKQEHGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKIALESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |